Aldolase

Aldolase is a glycolytic enzyme that is present in all body cells. The highest concentrations of aldolase are found in the cells of skeletal muscles, the heart, and liver tissue, although the test is considered most specific for muscle tissue destruction. When damage to muscle tissue occurs, cells are destroyed, resulting in the release of aldolase into the blood. Thus, testing for aldolase is useful in monitoring the progress of muscle damage in such disorders as muscular dystrophy.